Favorable outcome without corticosteroids during Post-Artesunate Delayed Haemolysis with positive Direct Antiglobulin Test in severe imported Plasmodium falciparum malaria, France

Post-artesunate delayed haemolysis (PADH) is a common non-recurring adverse effect of artesunate during severe P.falciparum malaria, which occurs after the first week of treatment in an estimated 10-30% of cases in non-immune travelers [1,2]. Reports of positive direct antiglobulin tests (DAT) in patients experiencing PADH suggest an immune-driven process [1,3]. In a systematic review, 44% of patients with PADH had a positive DAT [4]. Most prior reports focused only on patients experiencing PADH and not other patients with severe malaria.

Source: International Journal of Infectious Diseases - November 3, 2023 Category: Infectious Diseases Authors: Olivier Paccoud, Xavier Chamillard, Eric Kendjo, Isabelle Vinatier, Laure Surgers, Denis Magne, Benjamin Wyplosz, Ad éla Angoulvant, Olivier Bouchaud, Arezki Izri, Sophie Matheron, Sandrine Houzé, Marc Thellier, Alioune P. Ndour, Pierre Buffet, Eric Cau Tags: Short Communication Source Type: research