The Impact of Vaccination and SARS-CoV-2 Variants on the Virological Response to SARS-CoV-2 Infections during the Alpha, Delta, and Omicron waves in England

Vaccination status and the SARS-CoV-2 variant individuals are infected with are known to independently impact viral dynamics; however, little is known about the interaction of these two factors and how this impacts viral dynamics. Here we investigated how monovalent vaccination modified the time course and viral load of infections from different variants.Regression analyses were used to investigate the impact of vaccination on cycle threshold values and disease severity, and interval-censored survival analyses were used to investigate the impact of vaccination on duration of positivity.

Source: Journal of Infection - November 3, 2023 Category: Infectious Diseases Authors: Rachel Lunt, Catherine Quinot, Freja Kirsebom, Nick Andrews, Catriona Skarnes, Louise Letley, Donna Haskins, Catriona Angel, Skye Firminger, Kay Ratcliffe, Shelina Rajan, Angela Sherridan, Samreen Ijaz, Maria Zambon, Kevin Brown, Mary Ramsay, Jamie Lopez Source Type: research