The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases

Nature Reviews Cardiology, Published online: 03 November 2023; doi:10.1038/s41569-023-00946-3The NLRP3 inflammasome can sense cardiac ischaemic and non-ischaemic injury, amplify the inflammatory response and induce inflammatory cell death. In this Review, Toldo and Abbate describe the role of the NLRP3 inflammasome in numerous cardiac pathologies and summarize evidence on the use of agents targeting the NLRP3 inflammasome and related cytokines.
Source: Nature Reviews Cardiology - Category: Cardiology Authors: Source Type: research