Relationship between degree of methylation of sperm long interspersed nuclear element-1 (LINE-1) gene and alteration of sperm parameters and age: a meta-regression analysis

ConclusionsThe results of this systematic review and meta-analysis do not suggest a determining role of spermLINE1 gene methylation degree in patients with infertility and/or abnormal sperm parameters. Therefore, we do not suggest includingLINE1 in the genetic panel of prospective studies aimed at identifying the most representative and cost-effective genes to be analyzed in couples undergoing ART cycles.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research