Interplay of lipid metabolism and inflammation in podocyte injury
Podocytes are critical for maintaining permselectivity of the glomerular filtration barrier, and podocyte injury is a major cause of proteinuria in various primary and secondary glomerulopathies. Lipid dysmetabolism and inflammatory activation are the distinctive hallmarks of podocyte injury. Lipid accumulation and lipotoxicity trigger cytoskeletal rearrangement, insulin resistance, mitochondrial oxidative stress, and inflammation. Subsequently, inflammation promotes the progression of glomerulosclerosis and renal fibrosis via multiple pathways.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Zilv Luo, Zhaowei Chen, Jijia Hu, Guohua Ding Tags: Review Source Type: research