Neurological complications of excessive recreational nitrous oxide use: a case series based on a text mining algorithm

ConclusionsIn this case series of excessive N2O users, we describe a high prevalence of polyneuropathy, myelopathy, and encephalopathy. Stepwise testing for serum levels of vitamin B12, homocysteine, and methylmalonic acid may support the clinical diagnosis. Due to low sensitivity, MRI of the spinal cord and electromyography have limited value. Effective treatment should incorporate supplementation of vitamin B12 and strategies to prevent relapses in N2O use.
Source: Journal of Neurology - Category: Neurology Source Type: research