Multiple infusions of ex  vivo-expanded regulatory T cells promote CD163+ myeloid cells and kidney allograft survival in non-lymphodepleted non-human primates

Clinical verification of adoptively transferred regulatory T cell (Treg) efficacy in transplantation remains challenging. Here, we examined the influence of autologous ex  vivo-expanded polyclonal Tregs on kidney graft survival in a clinically relevant non-human primate model. Peripheral blood Tregs were isolated and expanded using artificial antigen presenting cells. Immunosuppression was comprised of tapered tacrolimus and CTLA4 immunoglobulin, in five animals eac h without or with Treg infusions.

Source: Kidney International - October 13, 2023 Category: Urology & Nephrology Authors: Kazuki Sasaki, Masahiko Kubo, Yu-chao Wang, Lien Lu, Veronica Vujevich, Michelle A. Wood-Trageser, Kayla Golnoski, Andrew Lesniak, Vikraman Gunabushanam, Armando Ganoza, Martin J. Wijkstrom, Abhinav Humar, Anthony J. Demetris, Angus W. Thomson, Mohamed B. Tags: Basic Research Source Type: research