5. Overcoming challenges in semantic alignment of therapeutics knowledge using TheraPy

Genomic medicine pipelines incorporate knowledge extracted from an increasing number of publicly available databases. Unfortunately, integration of data about drugs and other therapeutics remains challenging, as these concepts are often ambiguous and inconsistently described. Semantic alignment of this knowledge would enable richer genomic annotation and clinical decision support, but is hampered by incongruities regarding data structure and scope between knowledge sources. Individual therapeutics may be associated with a variety of related concepts, from developmental identifiers and IUPAC chemical structure names to active ingredients or brand names.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research