6. Tracking immunotherapy response with single cell T cell receptor profiling in canine models of cancer

Spontaneous cancers in companion dogs are increasingly recognized as robust models of human disease. The ability to track tumor-specific immune responses in these models would benefit from reagents to perform species-specific single cell T cell receptor sequencing (scTCRseq). To date, scTCRseq and its integration with scRNA data have not been demonstrated for canine samples. Five healthy dogs, two dogs with T cell lymphoma and four dogs with melanoma in a trial of an autologous deglycosylated melanoma vaccine were selected to demonstrate applicability of scTCRseq in a cancer immunotherapy setting.

Source: Cancer Genetics and Cytogenetics - November 1, 2023 Category: Genetics & Stem Cells Authors: Obi Griffith, Zachary Skidmore, Hans Rindt, Shirley Chu, Bryan Fisk, My Hoang, Catrina Fronick, Robert Fulton, Mingyi Zhou, Nathan Bivens, Carol Reinero, Malachi Griffith, Jeff Bryan Source Type: research