32. Whole transcriptome sequencing as a diagnostic tool for AML

Next generation sequencing (NGS) has revolutionized the field of genomics by enabling the rapid and cost-effective sequencing of entire genomes, exomes, and transcriptomes. Genomic profiling has become an indispensable tool for diagnosis and risk stratification in Acute Myeloid Leukemia (AML). While targeted DNA sequencing has become the gold standard to detect driver mutations in AML, transcriptome sequencing offers relevant advantages, such as: the possibility of gene expression profiling evaluation, detection of alternative splicing and gene fusions.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research