44. Frequency and etiology of cytogenetically cryptic oncogenic fusions in pediatric AML

Fusion genes created by chromosomal rearrangements are the most common oncogenic drivers in pediatric AML. Identifying the primary driver is critical for risk stratification and for developing therapeutic targets. In a series of 600 patients enrolled on Children's Oncology Group AML trial AAML1831 in progress, we determined the frequency of cryptic oncogenic fusions (COFs) in each of the major subgroups of recurring genetic abnormalities. Fusions detected by RNA sequencing and/or FISH were cryptic by karyotype analysis in 12.7% of cases.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research