85. Microfilter enrichment of Hodgkin and Reed-Sternberg (HRS) cells

Hodgkin lymphoma (HL) is a rare B-cell derived hematologic malignancy that affects the lymph nodes. Large, multinucleated Reed-Sternberg (50-100 µm) and mononuclear Hodgkin cells (20-30 µm) are pathognomonic features of HL. These cells are rare and associated with T-cell aggregates making isolation and characterization challenging. Previous methods employed to isolate Hodgkin and Reed-Sternberg (HRS) cells are technically challenging, time consuming, and produce limited outputs unsuitable for clinical assays, making an alternative methodology imperative for the continued study of HL.

Source: Cancer Genetics and Cytogenetics - November 1, 2023 Category: Genetics & Stem Cells Authors: Brianna Munnich, Becca Brown, Abdulrahman Saadalla, Richard Cote, Todd Fehniger, Siddarth Rawal, Kilannin Krysiak Source Type: research