86. Diagnostic challenges of high-grade myeloid malignancies with partial plasmacytoid dendritic cell differentiation

We describe a rare case of chronic myelomonocytic leukemia (CMML) showing an unusual pattern of progression to myeloid sarcoma with partial plasmacytoid dendritic cell (pDC) differentiation which is previously not been well-described in literature. A 71-year-old man, diagnosed with CMML five years back, developed progressive lymphadenopathy. Lymph node (LN) biopsy confirmed myeloid sarcoma with prominent ( ∼40%) pDC differentiation [dual TCF4/CD123 positivity by immunohistochemistry (IHC) and flow cytometry (FC) analysis (CD123bright/HLA-DR+/CD303+/CD2partial/CD7partial)].

Source: Cancer Genetics and Cytogenetics - November 1, 2023 Category: Genetics & Stem Cells Authors: Karen Nahmod, Roberto Miranda, Francisco Vega, Beenu Thakral, Naveen Pemmaraju, Sanam Loghavi, Fatima Jelloul, Wei Wang, Sa Wang, Tariq Muzzafar, Keyur Patel, Carlos Bueso-Ramos, L. Jeffrey Medeiros, Rashmi Kanagal-Shamanna Source Type: research