Adiponectin stimulates Sca1+CD34 − adipocyte precursor cells associated with hyperplastic expansion and beiging of brown and white adipose tissue

The adipocyte hormone adiponectin improves insulin sensitivity and there is an inverse correlation between adiponectin levels and type-2 diabetes risk. Previous research shows that adiponectin remodels the adipose tissue into a more efficient metabolic sink. For instance, mice that overexpress adiponectin show increased capacity for hyperplastic adipose tissue expansion as evident from smaller and metabolically more active white adipocytes. In contrast, the brown adipose tissue (BAT) of these mice looks “whiter” possibly indicating reduced metabolic activity.

Source: Metabolism - Clinical and Experimental - October 31, 2023 Category: Biomedical Science Authors: Marco Bauz á-Thorbrügge, Milica Vujičić, Belén Chanclón, Vilborg Palsdottir, Nicolas J. Pillon, Anna Benrick, Ingrid Wernstedt Asterholm Source Type: research