IL36{gamma} reduces macrophage phagocytosis in COPD

Conclusion: Increased levels of IL36 in COPD impair macrophage phagocytosis and activate fibroblasts that further stimulate macrophage inflammatory mediator release. As IL36 is upregulated by viruses, these results may be clinically relevant for acute COPD exacerbations.

Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Owles, H., Baker, J. R., Fenwick, P., Watson, C. K., Kasmi, K. C., Barnes, P. J., Donnelly, L. E. Tags: Airway cell biology and immunopathology Source Type: research