CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells

CONCLUSIONS AND IMPLICATIONS: SERCA2 dysfunction promotes PASMC phenotypic transition and pulmonary vascular remodeling by multiple mechanisms, which could be improved by SERCA2 agonist CDN1163.PMID:37899350 | DOI:10.1080/10641963.2023.2272062

Source: Clinical and Experimental Hypertension - October 29, 2023 Category: Cardiology Authors: Weimin Yu Qian Zhang Yixiang Qiu Hui Chen Xiaoyang Huang Li Xiao Gang Xu Siqi Li Pingping Hu Xiaoyong Tong Source Type: research