Analysis of intracranial pressure pulse waveform in studies on cerebrospinal compliance: a narrative review

Continuous monitoring of mean intracranial pressure (ICP) has been an essential part of neurocritical care for more than half a century. Cerebrospinal pressure –volume compensation, i.e. the ability of the cerebrospinal system to buffer changes in volume without substantial increases in ICP, is considered an important factor in preventing adverse effects on the patient’s condition that are associated with ICP elevation. However, existing assessment met hods are poorly suited to the management of brain injured patients as they require external manipulation of intracranial volume. In the 1980s, studies suggested that spontaneous short-term variations in the ICP signal over a single cardiac cycle, called the ICP pulse waveform, may provide informatio n on cerebrospinal compensatory reserve. In this review we discuss the approaches that have been proposed so far to derive this information, from pulse amplitude estimation and spectral techniques to most recent advances in morphological analysis based on artificial intelligence solutions. Each meth od is presented with focus on its clinical significance and the potential for application in standard clinical practice. Finally, we highlight the missing links that need to be addressed in future studies in order for ICP pulse waveform analysis to achieve widespread use in the neurocritical care se tting.

Source: Physiological Measurement - October 26, 2023 Category: Physiology Authors: Agnieszka Kazimierska, Romain Manet, Alexandra Vallet, Eric Schmidt, Zofia Czosnyka, Marek Czosnyka and Magdalena Kasprowicz Source Type: research