Metabolites of non-aureus staphylococci affect the ability of Staphylococcus aureus to adhere to and internalize into bovine mammary epithelial cells

This study investigated whether cell-free supernatants (SN) from four bovine non-aureus staphylococcal (NAS) isolates preventStaphylococcus aureus adhesion to and internalization into bovine mammary epithelial cells (MAC-T cells) and if so, to determine whether such effects were potentially associated with theS. aureus accessory gene regulator (agr) system. Overall, we demonstrated that all SN obtained from the NAS isolates promoted adhesion of aS. aureus agr+ strain to, yet reduced the internalization into MAC-T cells, while similar effects were not observed for itsagr− mutant strain. Our findings provide novel anti-virulence strategies for treating and controlling bovineS. aureus mastitis.
Source: Veterinary Research - Category: Veterinary Research Source Type: research