Synergistic Effects of Tranylcypromine and NRF2 inhibitor: A Repurposing Strategy for Effective Cancer Therapy

In this study, we investigated combining Tranylcypromine (TCP) with a number of well-characterized drugs. Among these combinations, ML385 exhibited synergistic effects in combination with TCP. Specifically, our results showed that the combination of TCP and ML385 resulted in a significant reduction in tumor proliferation while neither drug affected cancer cell growth meaningfully on its own. While further studies are needed to understand fully the extent of the synergistic efficacy, the underlying respective mechanisms and the potential side effects of this approach, our study has yielded a promising start for the development of an effective combination cancer therapy.PMID:37871186 | DOI:10.1002/cmdc.202300282
Source: ChemMedChem - Category: Chemistry Authors: Source Type: research