Radiotherapy combined with docetaxel alters the immune phenotype of HNSCC cells and results in increased surface expression of CD137 and release of HMGB1 of specifically HPV-positive tumor cells

CONCLUSION: Our data with the HPV-dependent release of HMGB1 and increased expression of CD137 following RCT provide a hint for increased immunogenicity underlining the better prognosis for HPV positive tumors following RCT.PMID:37857049 | PMC:PMC10589749 | DOI:10.1016/j.neo.2023.100944

Source: Neoplasia - October 19, 2023 Category: Cancer & Oncology Authors: Fridolin Grottker Simon Gehre Clara M Reichardt Azzaya Sengedorj Tina Jost Thorsten Rieckmann Markus Hecht Antoniu-Oreste Gostian Benjamin Frey Rainer Fietkau Udo S Gaipl Michael R ückert Source Type: research