Neurodegenerative Disease Tauopathies

Annu Rev Pathol. 2023 Oct 13. doi: 10.1146/annurev-pathmechdis-051222-120750. Online ahead of print.ABSTRACTTauopathies are a diverse group of progressive and fatal neurodegenerative diseases characterized by aberrant tau inclusions in the central nervous system. Tau protein forms pathologic fibrillar aggregates that are typically closely associated with neuronal cell death, leading to varied clinical phenotypes including dementia, movement disorders, and motor neuron disease. In this review, we describe the clinicopathologic features of tauopathies and highlight recent advances in understanding the mechanisms that lead to spread of pathologic aggregates through interconnected neuronal pathways. The cell-to-cell propagation of tauopathy is then linked to posttranslational modifications, tau fibril structural variants, and the breakdown of cellular protein quality control. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease, Volume 19 is January 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.PMID:37832941 | DOI:10.1146/annurev-pathmechdis-051222-120750
Source: Annual Review of Pathology - Category: Pathology Authors: Source Type: research