Succinic acid exacerbates experimental autoimmune uveitis by stimulating neutrophil extracellular traps formation via SUCNR1 receptor

Conclusions
Succinic acid could worsen EAU induced by IRBP in mice. This effect was possibly mediated by its upregulation on NETs generation and frequencies of Th1/Th17 cells in affiliation with increased production of IFN-/IL-17A through succinic acid-SUCNR1 axis.

Source: British Journal of Ophthalmology - October 20, 2023 Category: Opthalmology Authors: Li, H., Tan, H., Liu, Z., Pan, S., Tan, S., Zhu, Y., Wang, Q., Su, G., Zhou, C., Cao, Q., Yang, P. Tags: Original articles - Laboratory science Source Type: research