Deep Learning to Predict Breast Cancer Sentinel Lymph Node Status on INSEMA Histological Images

Sentinel lymph node status is a clinically important prognostic biomarker in breast cancer and is used to guide therapy, especially for hormone receptor-positive, HER2-negative cases. However, invasive lymph node staging is increasingly omitted before therapy and studies such as the randomized INSEMA trial address the potential for further de-escalation of axillary surgery. Therefore, it would be helpful to accurately predict the pre-therapeutic sentinel status using medical images.

Source: European Journal of Cancer - October 18, 2023 Category: Cancer & Oncology Authors: Frederik Marm é, Eva Krieghoff-Henning, Bernd Gerber, Max Schmitt, Dirk-Michael Zahm, Dirk Bauerschlag, Helmut Forstbauer, Guido Hildebrandt, Beyhan Ataseven, Tobias Brodkorb, Carsten Denkert, Angrit Stachs, David Krug, Jörg Heil, Michael Golatta, Thors Source Type: research