The authors reply

Wei et  al.1 argue that the observed outcome differences in our study addressing use of diuretics and calcium channel blockers (CCBs) on top of renin-angiotensin system inhibitors2 might be explained by residual confounding. Although this is a limitation of any observational study, including ours, we do n ot believe their concerns are likely to invalidate our findings. The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend maximum-tolerated renin-angiotensin system inhibitor dose for these patients.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research