Estimating the Genetic Contribution to Astigmatism and Myopia in the Mexican Population
This study aimed to estimate the genetic contribution to astigmatism and myopia in the Mexican population. A sample of 1399 families, including 243 twin pairs and 1156 single twins, completed a medical questionnaire about their own and their co-twin's diagnosis of astigmatism and myopia. Concordance rates for astigmatism and myopia were estimated, and heritability and genetic correlations were determined using a bivariate ACE Cholesky decomposition method, decomposed into A (additive genetic), C (shared environmental) and E (unique environmental) components. The results showed a higher concordance rate for astigmatism and myopia for MZ twins (.74 and .74, respectively) than for DZ twins (.50 and .55). The AE model, instead of the ACE model, best fitted the data. Based on this, heritability estimates were .81 for astigmatism and .81 for myopia, with a cross-trait genetic correlation of rA = .80, nonshared environmental correlation rE = .89, and a phenotypic correlation of rP = .80. These results are consistent with previous findings in other populations, providing evidence for a similar genetic architecture of these conditions in the multi-ethnic Mexican population.PMID:37842863 | DOI:10.1017/thg.2023.41
Source: Twin Research and Human Genetics - Category: Genetics & Stem Cells Authors: Tal ía V Román-López Brisa Garc ía-Vilchis Vanessa Murillo-Lechuga Enrique Chiu-Han Xanat L ópez-Camaño Oscar Aldana-Assad Santiago Diaz-Torres Ulises Caballero-S ánchez Ivett Ortega-Mora Diego Ram írez-González Diego Zenteno Zaida Espinosa-Vald Source Type: research
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