The role of gut-brain axis in a rotenone-induced rat model of Parkinson's disease
Neurobiol Aging. 2023 Jul 13;132:185-197. doi: 10.1016/j.neurobiolaging.2023.07.005. Online ahead of print.ABSTRACTParkinson's disease (PD) is a widespread neurodegenerative condition affecting millions globally. This investigation centered on the gut-brain axis in a rotenone-induced PD rat model. Researchers monitored behavioral shifts, histological modifications, neurodegeneration, and inflammation markers throughout the rats' bodies. Results revealed that rotenone-treated rats displayed reduced exploration (p = 0.004) and motor coordination (p < 0.001), accompanied by decreased Nissl staining and increased alpha-synuclein immunoreactivity in the striatum (p = 0.009). Additionally, these rats exhibited weight loss (T3, mean = 291.9 ± 23.67; T19, mean = 317.5 ± 17.53; p < 0.05) and substantial intestinal histological alterations, such as shortened villi, crypt architecture loss, and inflammation. In various regions, researchers noted elevated immunoreactivity to ionized binding adapter molecule (IBA)-1 (p < 0.05) and reduced immunoreactivity to glial fibrillary acidic protein (p < 0.05) and S100B (p < 0.001), indicating altered glial cell activity. Overall, these findings imply that PD is influenced by gut-brain axis changes and may originate in the intestine, impacting bidirectional gut-brain communication.PMID:37837734 | DOI:10.1016/j.neurobiolaging.2023.07.005
Source: Neurobiology of Aging - Category: Geriatrics Authors: J úlio César Claudino Dos Santos Concei ção da Silva Martins Rebouças Leandro Freitas Oliveira Fabrizio Dos Santos Cardoso Tyciane de Souza Nascimento Alfaete Vieira Oliveira Micael Porto Portela Lima Geanne Matos de Andrade Gerly Anne de Castro Brit Source Type: research