Dual effect of tacrolimus on mast cell –mediated allergy and inflammation through Mas-related G protein-coupled receptor X2

Topical tacrolimus, although widely used in the treatment of dermatoses, presents with an immediate irritation on initial application resembling a pseudo-allergic reaction. Mas-related G protein-coupled receptor X2 (MRGPRX2) in mast cells (MCs) mediates drug-induced pseudo-allergic reaction and immunoglobulin E (IgE)-independent pruritis in chronic skin diseases. However, the immunosuppression mechanism of tacrolimus on MCs via MRGPRX2 has not been reported.

https://www.jdsjournal.com/article/S0923-1811(23)00226-8/fulltext?rss=yes

Source: Journal of Dermatological Science - October 17, 2023 Category: Dermatology Authors: Xueshan Du, Delu Che, Bin Peng, Yi Zheng, Yong Hao, Tao Jia, Xinyue Zhang, Songmei Geng Source Type: research