HIV-1 subtypes maintain distinctive physicochemical signatures in Nef domains associated with immunoregulation

CONCLUSIONS: Recent studies have focused on HIV Nef as a driver of immunoregulatory disease in those HIV infected and on ART. Nef acts through a complex mixture of interactions that are directly linked to the key features of the subtype-specific domains we identified with the ENN. The study supports the hypothesis that varied Nef subtypes contribute to subtype-specific disease progression.PMID:37832752 | DOI:10.1016/j.meegid.2023.105514

Source: Infection, Genetics and Evolution - October 13, 2023 Category: Genetics & Stem Cells Authors: Susanna L Lamers Gary B Fogel Enoch S Liu David J Nolan Rebecca Rose Michael S McGrath Source Type: research