Metabolic reprogramming unlocks the regenerative potential of the heart

Nature Reviews Cardiology, Published online: 13 October 2023; doi:10.1038/s41569-023-00945-4The metabolic maturation of mammalian cardiomyocytes that occurs during the early postnatal period shapes the epigenetic landscape of cardiomyocytes and creates a barrier for cell division, but reversing this remodelling process can restore the reparative capacity of the heart in mice, according to a study published in Nature.

Source: Nature Reviews Cardiology - October 13, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research