Cartilage-specific Sirt6 deficiency represses IGF-1 and enhances osteoarthritis severity in mice

Conclusions
SIRT6 deficiency increases post-traumatic and age-associated OA severity in vivo. SIRT6 profoundly regulated the pro-anabolic and pro-survival IGF-1/Akt signalling pathway and suggests that preserving the SIRT6/IGF-1/Akt axis may be necessary to protect cartilage from injury-associated or age-associated OA. Targeted therapies aimed at increasing SIRT6 function could represent a novel strategy to slow or stop OA.

Source: Annals of the Rheumatic Diseases - October 12, 2023 Category: Rheumatology Authors: Collins, J. A., Kim, C. J., Coleman, A., Little, A., Perez, M. M., Clarke, E. J., Diekman, B., Peffers, M. J., Chubinskaya, S., Tomlinson, R. E., Freeman, T. A., Loeser, R. F. Tags: Open access, ARD, Osteoarthritis Source Type: research