Chronic inflammatory conditions of the placenta

Placental inflammatory conditions comprise a main diagnostic category in placental pathology. Placental inflammation can broadly be categorised into acute and chronic, with co-existence of both in the same placenta also possible. Chronic inflammation may be of infectious or non-infectious aetiology. TORCH infections represent the majority of placental infections associated with chronic inflammation in developed countries. Non-infectious chronic placental inflammatory conditions, such as villitis of unknown aetiology (VUE) and chronic histiocytic intervillositis (CHI) are currently attributed to immune-mediated mechanisms and aetiology, and have been associated with significant implications such as miscarriage, stillbirth, premature delivery, intra-uterine growth restriction, poor neurological outcome in living babies, and recurrence risk in future pregnancies.
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Mini-symposium: paediatric and perinatal pathology Source Type: research