Influence of < em > CYP2C19 < /em > , < em > CYP2D6 < /em > , and < em > ABCB1 < /em > Gene Variants and Serum Levels of Escitalopram and Aripiprazole on Treatment-Emergent Sexual Dysfunction: A Canadian Biomarker Integration Network in Depression 1 (CAN-BIND 1) Study

CONCLUSIONS: CYP2C19 metabolizer phenotypes may be influencing changes in sexual arousal related to ESC monotherapy. Thus, preemptive genotyping of CYP2C19 may help to guide selection of treatment that circumvents selective serotonin reuptake inhibitor-related sexual dysfunction thereby improving outcomes for patients. Additionally, further research is warranted to clarify the role of S-DCT in the mechanisms underlying ESC-related changes in SF and SS. This CAN-BIND-1 study was registered on clinicaltrials.gov (Identifier: NCT01655706) on 27 July 2012.PMID:37796764 | DOI:10.1177/07067437231203433

Source: Canadian Journal of Psychiatry - October 5, 2023 Category: Psychiatry Authors: Farhana Islam Leen Magarbeh Samar S M Elsheikh Stefan Kloiber Caroline W Espinola Venkat Bhat Benicio N Frey Roumen Milev Claudio N Soares Sagar V Parikh Franca Placenza Stefanie Hassel Valerie H Taylor Francesco Leri Pierre Blier Rudolf Uher Faranak Farz Source Type: research