Multivalent tyrosine kinase inhibition promotes T cell recruitment to immune-desert gastric cancers by restricting epithelial-mesenchymal transition via tumour-intrinsic IFN-{gamma} signalling

Conclusion
Our findings identified potential druggable targets relevant to patient groups, especially for refractory immune desert-type/ ‘cold’ GC. Dovitinib, an RTK inhibitor, sensitised desert-type immune-cold GC to CTLA4 blockade by restricting EMT and recruiting T cells.

Source: Gut - October 6, 2023 Category: Gastroenterology Authors: Cao, L. L., Lu, H., Soutto, M., Bhat, N., Chen, Z., Peng, D., Gomaa, A., Wang, J. B., Xie, J. W., Li, P., Zheng, C. H., Nomura, S., Datta, J., Merchant, N., Chen, Z. B., Villarino, A., Zaika, A., Huang, C. M., El-Rifai, W. Tags: Gut Stomach Source Type: research