Impact of Bmal1 rescue and time-restricted feeding on liver and muscle proteomes during the active phase in mice

CONCLUSIONS: In liver and muscle, BMAL1 is a more potent regulator of dark phase proteomes than daily feeding cycles, highlighting the need to assess protein levels in addition to mRNA when investigating clock mechanisms. The proteome is more extensively regulated by BMAL1 in liver than in muscle and many metabolic pathways in peripheral tissues are reliant on the function of the clock system as a whole.PMID:37793502 | DOI:10.1016/j.mcpro.2023.100655

Source: Molecular and Cellular Proteomics : MCP - October 4, 2023 Category: Molecular Biology Authors: Jacob G Smith Jeffrey Molendijk Ronnie Blazev Wan Hsi Chen Qing Zhang Christopher Litwin Valentina M Zinna Patrick-Simon Welz Salvador Aznar Benitah Carolina M Greco Paolo Sassone-Corsi Pura Mu ñoz-Cánoves Benjamin L Parker Kevin B Koronowski Source Type: research