Cancers, Vol. 15, Pages 4860: Synovial Sarcoma in the Extremity: Diversity of Imaging Features for Diagnosis and Prognosis

Cancers, Vol. 15, Pages 4860: Synovial Sarcoma in the Extremity: Diversity of Imaging Features for Diagnosis and Prognosis Cancers doi: 10.3390/cancers15194860 Authors: Eun Byul Cho Seul Ki Lee Jee-Young Kim Yuri Kim Synovial sarcomas are rare and highly aggressive soft-tissue sarcomas, primarily affecting adolescents and young adults aged 15–40 years. These tumors typically arise in the deep soft tissues, often near the large joints of the extremities. While the radiological features of these tumors are not definitely indicative, the presence of calcification in a soft-tissue mass (occurring in 30% of cases), adjacent to a joint, strongly suggests the diagnosis. Cross-sectional imaging characteristics play a crucial role in diagnosing synovial sarcomas. They often reveal significant characteristics such as multilobulation and pronounced heterogeneity (forming the “triple sign”), in addition to features like hemorrhage and fluid–fluid levels with septa (resulting in the “bowl of grapes” appearance). Nevertheless, the existence of non-aggressive features, such as gradual growth (with an average time to diagnosis of 2–4 years) and small size (initially measuring < 5 cm) with well-defined margins, can lead to an initial misclassification as a benign lesion. Larger size, older age, and higher tumor grade have been established as adverse predictive indicators ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research