An enterovirus A71 virus-like particle with replaced loops confers partial cross-protection in mice

In conclusion, the successful construction of EV-A71-VLPCHI3 suggested that loop-dependent heterologous protection could be transferred by loops replacement on the surface of viral capsid. This strategy may also supplement the development of multivalent vaccines against other infectious viral diseases.PMID:37788720 | DOI:10.1016/j.virusres.2023.199235

Source: Virus Research - October 3, 2023 Category: Virology Authors: Xin Liu Hanyu Zhu Mei Wang Ning Zhang Jing Wang Wenbian Tan Guochuan Wu Pei Yu Hongbo Liu Qiliang Liu Source Type: research