Circulating concentrations of advanced glycation end products, carboxymethyl lysine and methylglyoxal are associated with renal function in individuals with diabetes

Diabetic kidney disease (DKD) is one of the most severe chronic complication of diabetes, and is associated with higher level of advanced glycation end-products (AGEs). The aim of this study was to investigate the diagnostic potential of combined detection of multiple serum AGEs in diagnosing DKD. Methods: Serum AGEs, N ε-(carboxymethyl) lysine (CML), Nε-(carboxyethyl) lysine (CEL) and methylglyoxal (MGO) levels were measured by ELISA in 176 individuals with type 2 diabetes (T2D). Participants were classified into normo- (NAU group), micro- (MAU group) and macroalbuminuria group (MAAU group) according to their ur inary albumin to creatinine ratio (UACR).
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Authors: Tags: Original Research Source Type: research