Coronavirus-19 disease risk and protective factors associated with HLA/KIR polymorphisms in Ecuadorian patients residing in Madrid

CONCLUSION: HLA-B*39 alleles might be genetic risk factors for developing COVID-19 in Ecuadorian individuals. In the presence of its ligand C*04, the natural killer-activating receptor KIR2DS4 might also increase the risk of developing COVID-19, while, in the presence of HLA-Bw4 alleles, the inhibitory receptor KIR3DL1 might play a protective role. Patients with COVID-19 who carry HLA-A*24:02 and HLA-DRB1*09:01 alleles might be protected against more severe forms of COVID-19.PMID:37777360 | DOI:10.1016/j.humimm.2023.09.004

Source: Human Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Antonio Balas Miguel Ángel Moreno-Hidalgo Fernando de la Calle-Prieto Jos é Luis Vicario Marta Arsuaga Elena Trigo Rosa de Miguel-Buckley Teresa Bell ón Marta D íaz-Menéndez Source Type: research