P132 Quantifying skeletal muscle fat fraction and function using whole body magnetic resonance imaging (MRI) in men with Becker muscular dystrophy

Becker Muscular Dystrophy (BMD) results in impaired function of dystrophin and leads to fat replacement of skeletal muscle impacting function. There is a growing interest in drug development for BMD, and biomarkers that characterize muscle quality and their relationships to function are needed. Quantitative magnetic resonance (qMR) imaging of muscle fat fraction (FF) is highly reliable and sensitive to disease progression in muscular dystrophy. Whole-body quantitative three-point Dixon (3PD) imaging (WBI) has efficient acquisition and the ability to analyze multiple muscles to develop body segment-specific FF composites.

Source: Neuromuscular Disorders - October 1, 2023 Category: Neurology Authors: K. Rock, R. Willcocks, S. Forbes, A. Barnard, D. Lott, B. Smith, S. Prabhakaran, W. Rooney, M. Daniels, S. Subramony, N. Chahin, G. Walter, K. Vandenborne Source Type: research