P225 Longitudinal changes in compound muscle action potential and their association with motor function in infantile-onset SMA children in ENDEAR/SHINE

Compound muscle action potential (CMAP) is a non-invasive, and simple-to-perform electrophysiological technique that can be used to provide physiologic information about motor units. Understanding the longitudinal changes of CMAP and their association with motor function outcomes in children with Spinal Muscular Atrophy (SMA) can help evaluate CMAP as a potential biomarker for therapeutic effects in SMA. Our analysis included 105 participants with infantile-onset SMA who initiated nusinersen in ENDEAR or long-term extension study SHINE (27 Aug 2019 datacut).
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research