P328 Investigations of the specific interferon-signature in anti-synthetase syndrome-associated myositis

Myositis affects skeletal muscles, but may also feature multi-systemic organ involvement, which might be life threatening. Patients are classified based on clinical and morphological factors due to international criteria. Additionally, in recent years two major achievements have emerged: First, autoantibodies (Ab) have become a key pillar in diagnostics, used to classify subtypes of myositis. E.g., Dermatomyositis (DM) patients show a strong cancer-association when harboring TIF1g-Ab, while MDA5+ DM do not, but the often show ILD.

Source: Neuromuscular Disorders - October 1, 2023 Category: Neurology Authors: C. Preusse, L. Gallay, I. Pinal-Fernandez, A. Mammen, O. Benveniste, H. Goebel, N. Streichenberger, A. Roos, T. Ruck, W. Stenzel Source Type: research