Advances in screening, synthesis, modification, and biomedical applications of peptides and peptide aptamers

This comprehensive review explores the latest advancements in the screening, synthesis, modification, and biomedical applications of peptides and peptide aptamers. It discusses screening techniques, diverse synthesis strategies, and various modification approaches employed to enhance their properties. The review also highlights the broad range of biomedical applications where peptides and peptide aptamers have shown promise, including drug delivery, therapeutics, diagnostics, and biomaterials. AbstractPeptides and peptide aptamers have emerged as promising molecules for a wide range of biomedical applications due to their unique properties and versatile functionalities. The screening strategies for identifying peptides and peptide aptamers with desired properties are discussed, including high-throughput screening, display screening technology, and in silico design approaches. The synthesis methods for the efficient production of peptides and peptide aptamers, such as solid-phase peptide synthesis and biosynthesis technology, are described, along with their advantages and limitations. Moreover, various modification techniques are explored to enhance the stability, specificity, and pharmacokinetic properties of peptides and peptide aptamers. This includes chemical modifications, enzymatic modifications, biomodifications, genetic engineering modifications, and physical modifications. Furthermore, the review highlights the diverse biomedical applications of peptides and peptide a...
Source: BioFactors - Category: Biochemistry Authors: Tags: REVIEW ARTICLE Source Type: research