Role of human epidermal growth factor receptor 3 in treatment resistance of anaplastic lymphoma kinase translocated non-small cell lung cancer

CONCLUSIONS: This study provides evidence that HER3 may mediate TKI resistance in ALK+ NSCLC. Interestingly, we were able to show that both translocated ALK and HER3 could interact. Joint targeting of ALK and HER3 could be further investigate in ALK+ NSCLC.PMID:37722715 | PMC:PMC10512822 | DOI:10.1080/15384047.2023.2256906
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Source Type: research