PRICKLE1 gene methylation and abnormal transcription in Chinese patients with ankylosing spondylitis

CONCLUSION: There is a significant change in the concentration of serum PRICKLE1 mRNA​in patients with Ankylosing spondylitis, and the degree of gene methylation is significantly reduced, suggesting that PRICKLE1 gene maybe involved in the pathogenesis of Ankylosing spondylitis, which may be useful for predicting the occurrence of AS and finding new early screening indicators.PMID:37742487 | DOI:10.1016/j.imbio.2023.152742

Source: Immunobiology - September 24, 2023 Category: Allergy & Immunology Authors: Tingting Zhou Xinqi Wang Jiangping Kong Lingxiang Yu Huimin Xie Feier Wang Shenqian Xu Zongwen Shuai Qiang Zhou Faming Pan Source Type: research