Protective efficacy of pirfenidone in rats with pulmonary fibrosis induced by bleomycin

CONCLUSIONS: Pirfenidone had a statistically significant protective effect in bleomycin-induced lung fibrosis and pleuritis in rats. Despite the presence of inflammation in the tissue, no significant changes were observed in inflammation markers in the peripheral blood. Novel serum biomarkers are needed to indicate the presence of inflammation and fibrosis in the lung.PMID:37712376 | DOI:10.36141/svdld.v40i3.13847

Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Baris Demirkol Sule Gul Mustafa C örtük Neslihan Akan ıl Fener Emineg ül Yavuzsan Ramazan Eren Kursad Nuri Baydili Mustafa Baki Çekmen Erdogan Cetinkaya Source Type: research