Microglia moonlighting after traumatic brain injury: aging and interferons influence chronic microglia reactivity

Trends Neurosci. 2023 Sep 16:S0166-2236(23)00206-0. doi: 10.1016/j.tins.2023.08.008. Online ahead of print.ABSTRACTMost of the individuals who experience traumatic brain injury (TBI) develop neuropsychiatric and cognitive complications that negatively affect recovery and health span. Activation of multiple inflammatory pathways persists after TBI, but it is unclear how inflammation contributes to long-term behavioral and cognitive deficits. One outcome of TBI is microglial priming and subsequent hyper-reactivity to secondary stressors, injuries, or immune challenges that further augment complications. Additionally, microglia priming with aging contributes to exaggerated glial responses to TBI. One prominent inflammatory pathway, interferon (IFN) signaling, is increased after TBI and may contribute to microglial priming and subsequent reactivity. This review discusses the contributions of microglia to inflammatory processes after TBI, as well as the influence of aging and IFNs on microglia reactivity and chronic inflammation after TBI.PMID:37723009 | DOI:10.1016/j.tins.2023.08.008
Source: Trends in Neurosciences - Category: Neuroscience Authors: Source Type: research