Molecules, Vol. 28, Pages 6760: Compatibility of Nucleobases Containing Pt(II) Complexes with Red Blood Cells for Possible Drug Delivery Applications

In this study, we evaluated the feasibility of loading model nucleobase-containing Pt(II) complexes into human RBCs that were highly stabilized by four N-donors and susceptible to further modification for possible antitumor/antiviral applications. Specifically, platinum-based nucleoside derivatives [PtII(dien)(N7-Guo)]2+, [PtII(dien)(N7-dGuo)]2+, and [PtII(dien)(N7-dGTP)] (dien = diethylenetriamine; Guo = guanosine; dGuo = 2′-deoxy-guanosine; dGTP = 5′-(2′-deoxy)-guanosine-triphosphate) were investigated. These Pt(II) complexes were demonstrated to be stable species suitable for incorporation into RBCs. This result opens avenues for the possible incorporation of other metalated nucleobases analogues, with potential antitumor and/or antiviral activity, into RBCs.

Source: Molecules - September 22, 2023 Category: Chemistry Authors: Federica De Castro Erika Stef àno Francesco Paolo Fanizzi Riccardo Di Corato Pasant Abdalla Francesca Luchetti Maria Gemma Nasoni Rosaria Rinaldi Mauro Magnani Michele Benedetti Antonella Antonelli Tags: Article Source Type: research