Brain age prediction across the human lifespan using multimodal MRI data

AbstractMeasuring differences between an individual ’s age and biological age with biological information from the brain have the potential to provide biomarkers of clinically relevant neurological syndromes that arise later in human life. To explore the effect of multimodal brain magnetic resonance imaging (MRI) features on the prediction of brain age, we investigated how multimodal brain imaging data improved age prediction from more imaging features of structural or functional MRI data by using partial least squares regression (PLSR) and longevity data sets (age 6–85 years). First, we found that the age-predicted values for each of thes e ten features ranged from high to low: cortical thickness (R = 0.866, MAE = 7.904), all seven MRI features (R = 0.8594, MAE = 8.24), four features in structural MRI (R = 0.8591, MAE = 8.24), fALFF (R = 0.853, MAE = 8.1918), gray matter volume (R = 0.8324, MAE = 8.931), three rs-fMRI feature (R = 0.7959, MAE = 9.744), mean curvature (R = 0.7784, MAE = 10.232), ReHo (R = 0.7833, MAE = 10.122), ALFF (R = 0.7517, MAE = 10.844), and surface area (R = 0.719, MAE = 11.33). In addition, the significance of the volume and size of brain MRI data in predicting age was also studied. Second, our results suggest that all multimodal imaging features, except cortical thickness, improve brain-based age prediction. Third, we found that the left he misphere contributed more ...
Source: AGE - Category: Geriatrics Source Type: research