Development of a bupivacaine sustained release formulation for non-opioid analgesia following instrumented spinal surgery

Background: Patients undergoing instrumented spine surgery experience severe pain. Current opioid-based pain treatment provides a delicate balance between analgesic effect and side effects, delaying recovery. Local anesthetics such as bupivacaine have the potential to provide non-opioid pain relief, but are hampered by rapid systemic absorption and a duration of action that does not match the duration of severe pain. To enhance recovery after surgery through sustained and precise non-opioid pain treatment, BR-003 was developed.

Source: Clinical Nutrition ESPEN - September 21, 2023 Category: Nutrition Authors: Jasper Steverink, Floris van Tol, Kwame Amponsah, Hein Jonkman, Jessica Marvela, Suzanne Bruins, Andre Smorenburg, Bas Oosterman, Susanna Piluso, Jos Malda, Jorrit-Jan Verlaan Source Type: research