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Tacrolimus (TAC) is traditionally dosed by body weight. This approach often leads to underdosing and overdosing. In a prospective, randomized, open-label trial, Lloberas and colleagues compared traditional TAC dosing to dosing guided by a population pharmacokinetic (PPK) algorithm. The algorithm was based on age and CYP3A4, CYP3A5 genotypes that regulate TAC metabolism. Patients who received PPK-based dosing reached the target TAC trough level significantly more often than those who were dosed conventionally, and within a shorter timeframe.
Source: Kidney International - Category: Urology & Nephrology Tags: In This Issue Source Type: research